The association and diagnostic value of maternal serum placental biomarkers for fetal hypospadias and cryptorchidism.

ABSTRACT:

Background

Clinically, the diagnosis of hypospadias and cryptorchidism presents a certain degree of complexity due to the variability in anatomical presentation and potential comorbid conditions. This study aimed to evaluate the diagnostic value of maternal serum placental biomarkers [first-trimester (FT) gestation: 10-13⁺⁶ weeks; second-trimester (ST) gestation: 15-20⁺⁶ weeks] to predict hypospadias and cryptorchidism.

Methods

We performed a retrospective case-control study, and participants were divided into three groups: a hypospadias group (222 cases), a cryptorchidism group (120 cases), and a control group (311 cases). Receiver operating characteristic (ROC) curve, area under the curve (AUC), sensitivity, and specificity analyses were used to evalu

SUBMITTER: Jiang C 

PROVIDER: S-EPMC12268510 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature