Inflammatory Exposure and Depression in Older Adults With Insomnia: A Randomized Clinical Trial.

ABSTRACT:

Importance

Insomnia and inflammation are prevalent in older adults, and both are risk factors for late-life depression. Older adults with insomnia who are exposed to inflammatory challenge may be more vulnerable to depression.

Objective

To determine whether inflammatory exposure induces greater increases in depressive mood and symptoms in older adults with insomnia disorder compared to those without insomnia.

Design, setting, and participants

This assessor-blinded, parallel-condition randomized clinical trial was conducted from August 2017 to November 2022 at a single site in Los Angeles, California, among a community-based sample of 160 nondepressed adults aged 60 years or older (53 with insomnia disorder and 107 without insomnia, or control). Data analysis occurred

SUBMITTER: Irwin MR 

PROVIDER: S-EPMC12268530 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature