Role of radiotherapy in advanced oncogenic-driven oligometastatic non-small cell lung cancer patients: a narrative review.

ABSTRACT:

Background and objective

Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC), improving survival significantly. However, the integration of TKIs with radiotherapy (RT) for oligometastatic EGFR-mutant NSCLC remains an emerging strategy, with questions surrounding the optimal timing of RT intervention. This review seeks to examine recent insights into the timing of RT in relation to disease progression and to investigate the radiosensitizing effects of TKIs.

Methods

A comprehensive literature search was conducted using PubMed, Web of Science and ClinicalTrials.gov, focusing on studies from the three decades published in English. Key terms included "oncogenic-driven NSCLC", "ol

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12268550 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature