Vascular-type heterogeneity is associated with differential gene expression profiles of endothelial cells under shear stress.

ABSTRACT:

Background

Endothelial cell (EC) heterogeneity is an emerging area of research in EC biology. Vein, artery, and microvascular ECs have been shown to have heterogeneity in gene expression and function, termed "vascular-type" heterogeneity in this report. In addition to this innate heterogeneity, we hypothesized that different vascular-type ECs would also demonstrate heterogeneity in their response to shear stress.

Objectives

We interrogated whether vascular-type ECs would demonstrate variations in transcriptional expression patterns under shear stress.

Methods

Human umbilical vein ECs, human pulmonary arterial ECs, and human microvascular ECs were commercially purchased and subjected to 0, 1, 4, and 10 dynes/cm² of laminar shear stress. After shear stress ex

SUBMITTER: Cox AA 

PROVIDER: S-EPMC12268554 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature