Exploring Withania somnifera derived natural products as promising inhibitors of Mycobacterium tuberculosis Pantothenate Kinase-PanK: An integrated in silico and in vitro approach.

ABSTRACT:

Background

Tuberculosis remains a pervasive and enduring global health challenge, with the alarming rise of drug-resistant variants. Mycobacterium tuberculosis (M. tuberculosis), bacterium responsible for tuberculosis, deploys a complex arsenal of virulence factors to evade the host's immune defences. The quest for novel targets or compounds to combat drug-resistant M. tuberculosis strains is of paramount importance. PanK is an essential enzyme for Co-enzyme A (CoA) biosynthesis pathway, targeting inhibition of its activity by Withania somnifera phytochemicals may provide an effective therapeutic strategy against resistant strains.

Objective

The study aims to identify the potential of natural compounds derived from Withania somnifera as inhibitors of the PanK enzyme (novel t

SUBMITTER: Singh A 

PROVIDER: S-EPMC12268558 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature