Fluid management of cardiopulmonary bypass during pulmonary endarterectomy for CTEPH patients impacts perioperative outcome.

ABSTRACT:

Background

Pulmonary endarterectomy (PEA) using deep hypothermic circulatory arrest (DHCA) and cardiopulmonary bypass (CPB) is the preferred treatment for chronic thromboembolic pulmonary hypertension (CTEPH). Crystalloid priming solutions cause hemodilution with disadvantages, and no standard exists for PEA. This study evaluates CTEPH patient outcomes after adding 5% human albumin (HA) to the CPB-prime and hemodilution solution during PEA.

Methods

The effect of the CPB-protocol change was evaluated by comparing patients operated under the old and new protocols in a 1:1 propensity score match based on age, sex, and preoperative peripheral vascular resistance (PVR).

Results

Matching resulted in 56 patients (28 per group) between July 1, 2010, and May 31, 2020. The new

SUBMITTER: Furrer K 

PROVIDER: S-EPMC12268579 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature