Outcomes of radiotherapy combined with immune checkpoint inhibitors in locally advanced unresectable esophageal squamous cell carcinoma: a retrospective analysis.

ABSTRACT:

Background

The benefit of immune checkpoint inhibitors (ICIs) for esophageal cancer has been investigated and integrated into the treatment strategy. The integration of ICIs with radiotherapy offers significant potential for future applications in patients with locally advanced unresectable esophageal squamous cell carcinoma (ESCC). This study aimed to investigate the outcomes of ICIs combined with radiotherapy.

Methods

In this study, we enrolled patients with locally advanced unresectable ESCC who presented to Zhejiang Cancer Hospital between May 2019 and August 2021. The characteristics, survival outcomes, and toxicities of the patients were analyzed. Univariable and multivariable Cox regression analyses were performed to identify the factors associated with survival.

R

SUBMITTER: Lin Q 

PROVIDER: S-EPMC12268584 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature