A comparative study of the effects of spontaneous ventilation versus one-lung mechanical ventilation on ipsilateral lung injury during thoracic surgery: an empirical analysis based on a rat model.

ABSTRACT:

Background

One-lung ventilation (OLV) is prone to adverse reactions, particularly ventilator-induced lung injury (VILI). Spontaneous ventilation (SV) is supposed to reduce this risk. To investigate the effects of the ventilated lung during surgery, we established a rat model for research.

Methods

Forty-two rats were randomly divided into 7 groups: control, OLV, and SV [OLV/SV group was subdivided into 3 time points (10, 20, 30 min)]. Blood gas analysis, bronchoalveolar lavage fluid (BALF) test, and lung tissue wet-to-dry ratio were performed. Hematoxylin and eosin (HE), Masson and immunohistochemical for tumor necrosis factor-α (TNF-α) examinations were conducted.

Results

At 30 minutes of ventilation, compared to the OLV group, the SV group had higher arterial oxygen

SUBMITTER: Liao S 

PROVIDER: S-EPMC12268598 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature