Causality of genetically determined gut microbiota on lung cancer: a Mendelian randomization study.

ABSTRACT:

Background

Lung cancer (LC) is a growing global health concern, characterized by a persistent static 5-year survival rate and a worrisome increase in LC-related deaths. Despite substantial research, the connection between gut microbiota and LC remains a topic of ongoing debate. Conventional observational studies are susceptible to potential confounders and inverse causation. This study aims to investigate the potential causal association between gut microbiota and LC by using Mendelian randomization (MR).

Methods

There were 5,717,754 gut microbiota-related single-nucleotide polymorphisms (SNPs) identified from the MiBioGen consortium (18,340 participants from 24 cohorts) used as instrumental variables in our study. Gut microbiota composition was measured using 16S rRNA seque

SUBMITTER: Yu H 

PROVIDER: S-EPMC12268612 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature