Serum klotho is inversely associated with girth in older women but is not associated with falls or musculoskeletal measures in either sex.

ABSTRACT:

Objective

Serum klotho, a biomarker of aging, has been associated with cardiovascular disease, kidney disease, and osteoarthritis, but information on an association with muscle and bone aging is limited. We assessed serum klotho as a potential biomarker of age-related changes in body composition, odds of falling, muscle strength and bone mineral density (BMD) in older adults.

Design

Exploratory analysis within the STOP IT clinical trial.

Setting

USDA Human Nutrition Research Center on Aging at Tufts University.

Participants

Healthy adults (178 men; 209 women) age ≥65 years treated daily for 3 years with either 700 IU of vitamin D₃ plus 500 mg of calcium or placebo.

Methods

We examined associations of serum klotho (at 6 or 12 months) with odds

SUBMITTER: Dawson-Hughes B 

PROVIDER: S-EPMC12268625 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature