Role of miR-26b in regulating non-small cell lung cancer progression via targeting RCN1.

ABSTRACT:

Background

Dysregulated microRNAs (miRNAs) play a crucial role in the progression of non-small cell lung cancer (NSCLC) through post-transcriptional gene regulation. Although miR-26b has been implicated in tumor suppression, its epigenetic regulation and functional targets in NSCLC remain poorly understood. DNA methylation is a well-established modulator of miRNA expression; however, the specific role of miR-26b hypermethylation and its interaction with oncogenic pathways, particularly reticulocalbin-1 (RCN1), have not been fully elucidated. This study aims to clarify the miR-26b/RCN1 regulatory axis in NSCLC pathogenesis. By establishing this mechanism, we seek to identify novel therapeutic strategies and improve patient outcomes.

Methods

We first quantified the expression

SUBMITTER: Chen X 

PROVIDER: S-EPMC12268633 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature