Living hydrogel with blood derived elements for wound healing.

ABSTRACT: Blood plays a vital role in wound healing, as platelets (PLTs) initiate primary hemostasis and red blood cells (RBCs) continuously supply oxygen. Inspired by the intrinsic functions of RBCs and PLTs, we developed a living hydrogel incorporating RBCs, PLTs, and black phosphorus quantum dots (BP QDs) to accelerate wound healing. Owing to its three-dimensional (3D) pleated surface structure and excellent biocompatibility, the hydrogel exhibited enhanced cell seeding efficiency and provided effective support for both hemostasis and tissue regeneration. By leveraging the photo-responsive properties of BP QDs, the hydrogel acquired a controllable photothermal effect, enabling NIR-triggered oxygen release. Additionally, polymyxin was incorporated into the hydrogel matrix to endow the material wit

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC12268663 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature