Single atom-substituted gold nanoclusters for alleviating neural injury induced by deep hypothermic circulatory arrest.

ABSTRACT:

Background

Neurological deficit is a common complication of deep hypothermic circulatory arrest (DHCA). Among the diverse factors contributing to neural injury, oxidative stress plays a prominent role. Emerging nanocluster technology has demonstrated considerable antioxidant and anti-inflammation activity. In this study, we developed a novel type of nanocluster for the treatment of neural injury induced by DHCA.

Methods

Single atom-substituted gold nanoclusters (AuNCs) were synthesized. PC-12 cells subjected to oxygen-glucose deprivation/reoxygenation (OGD/R) and a rat DHCA model were employed. Cell viability was evaluated via Cell Counting Kit-8 (CCK-8). Histopathological changes in the hippocampus were evaluated by hematoxylin-eosin staining. S100 calcium-binding protein β

SUBMITTER: Wang J 

PROVIDER: S-EPMC12268667 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature