Up-regulated vitronectin in Kawasaki disease shock syndrome serves as a potential biomarker.

ABSTRACT:

Background

Kawasaki disease shock syndrome (KDSS) pathogenesis involves an immune inflammatory response related to Kawasaki disease (KD) that damages microvessel endothelial cells, leading to microcirculatory disorders. Its clinical manifestations are characterized by hypotension, poor peripheral perfusion, and a high risk of coronary artery lesions (CALs). Currently, there are few reports on biomarkers based on endothelial cell dysfunction in KDSS. This study aims to identify potential biomarkers of endothelial dysfunction in KDSS at the protein level.

Methods

In this study, we recruited age- and sex-matched participants, consisting of KDSS patients, KD patients, and healthy control (HC) children. The inflammatory indicators and cytokines were compared between the KD and KD

SUBMITTER: Wei Z 

PROVIDER: S-EPMC12268671 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature