Chest wall strapping in a porcine model: Dynamic dysanapsis dilates airways for optimized function of the "oversized" lung.

ABSTRACT: Chest-Wall-Strapping (CWS), a technique forcing the lung to operate at low volumes, is a model for an oversized lung allograft. Dynamic-dysanapsis describes airway dilation mediated by increased elastic recoil from CWS. We hypothesized that Dynamic-dysanapsis can be quantified via the Dysanapsis-Ratio, defined as the airway-size to lung-volume ratio. Farm-raised pigs (n=3) were mechanically ventilated. Stepwise CT-images throughout the lung deflation limb in control and CWS conditions were analyzed quantifying airway dimensions and lung volume. CWS (30%-reduction in lung-volume) was associated with a significant increase in the Dysanapsis-Ratio (p<0.001). CWS increased airway distensibility at the 6th major branch of the right lower airway (27±7% vs. 39±5%, p=0.04). The dysanapsis-ratio al

SUBMITTER: Abston E 

PROVIDER: S-EPMC12268676 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature