Alterations in the gut microbiota in individuals with infantile cholestasis: a comparison of high- and low-γ-glutamyltransferase subtypes.

ABSTRACT:

Background

There are two subtypes of infantile cholestasis (IC): high-γ-glutamyltransferase (GGT) and low-GGT (LG) cholestasis. This study aims to investigate the differences in the gut microbiota between infants with cholestasis and healthy infants and the correlations between the gut microbiota and blood or urine metabolites associated with high-GGT (HG) and LG IC subtypes.

Methods

A total of 37 infants were recruited into the cholestasis (Cho) group, including 21 infants with HG and 16 infants with LG levels, with 23 infants included in the control (Con) group. The gut microbiota composition was comprehensively analyzed, as were blood and urine metabolites, clinical indicators, and their correlations. The study was registered in both the Chinese Clinical Trial Registry (w

SUBMITTER: Lin Y 

PROVIDER: S-EPMC12268681 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature