Targeting Urease: A Promising Adjuvant Strategy for Effective <i>Helicobacter pylori</i> Eradication.

ABSTRACT: Helicobacter pylori, a Gram-negative bacterium, exhibits unique adaptations to thrive in an acidic gastric environment. Urease enzyme present in the bacteria converts urea to ammonia and carbon dioxide, making the surrounding acidic environment of the bacteria neutral. This adaptation helps the bacteria to survive and travel further to gastric epithelial cells, where it attaches to mucin and damages the tissues, leading to gastritis, peptic ulcer, and ultimately, cancer. Physicians typically prescribe first-, second-, and third-line antibiotic therapies to eliminate the bacterium, but these treatments frequently fail to achieve complete eradication. This failure, driven by factors such as the coccoid form, high bacterial load, and biofilm formation, contributes to the growing proble

SUBMITTER: Kunkalienkar S 

PROVIDER: S-EPMC12268749 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature