Daily validation using a metabolic simulator after regular calibration increases the quality of cardiopulmonary exercise testing.

ABSTRACT:

Background

Gas exchange measurements, such as oxygen uptake ( V˙O2 ) and carbon dioxide output ( V˙CO2 ), of cardiopulmonary exercise testing (CPET), are the key and gold standard for human cardiopulmonary functional evaluation. However, in terms of quality control, they are unstable and inaccurate. We used a metabolic simulator (MS) to detect measurement errors and enhance quality control.

Methods

In the Fuwai CPET laboratory, we performed CPET after systems had: (I) passed all the steps of regular system calibrations for flow and the partial pressure of O₂ and CO₂; and (II) passed the MS validation of V˙O2 and V˙CO2 at low, medium, and high metabolic rates (MRs) daily from 2014 to 2023 for eight different CPET carts/systems. The absolute percentage di

SUBMITTER: Xu F 

PROVIDER: S-EPMC12268752 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature