Vitamin D-regulated miRNA expression in tumoral and normal adjacent tissue of localized gastric cancer patients: the impact on survival and time to relapse.

ABSTRACT:

Background

Gastric cancer (GC) is driven by genetic, epigenetic, and environmental factors, with dysregulated microRNAs (miRNAs) influencing key biological processes and vitamin D signaling through vitamin D receptor modulation, impacting tumor prognosis. The aim of this study is to correlate the expression of vitamin D-related miRNAs in tumor tissue and normal adjacent tissue (NAT) in GC with patient survival.

Methods

The study involved 77 patients with localized GC, with time to relapse (TTR) and overall survival (OS) as primary and secondary endpoints, respectively. The study investigated miRNA expression levels in NAT and tumor and their association with patient characteristics.

Results

The analysis revealed that miR-106b, miR-181b-5p, miR-181a-5p and miR-181d-5p

SUBMITTER: Cousillas Castineiras A 

PROVIDER: S-EPMC12268756 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature