Potential biomarker for screening nasopharyngeal carcinoma: three-microRNA panel in serum.

ABSTRACT:

Background

Nasopharyngeal carcinoma (NPC) is a prevalent form of cancer in Southeast Asia, characterized by distinctive epidemiological attributes, and its occurrence is influenced by factors such as race, age, and gender. Prior research has highlighted the potential of serum microRNA (miRNA) profiling as a non-invasive biomarker for cancer detection. The objective of this study was to ascertain the miRNAs that are specifically linked to the diagnosis of NPC.

Methods

A three-phase study was conducted, involving a total of 112 participants (56 NPC patients and 56 healthy controls). Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was employed to measure the expression levels of miRNAs in NPCs and healthy controls (HCs). The diagnostic capability of serum

SUBMITTER: Li X 

PROVIDER: S-EPMC12268783 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature