Interleukin-11 promotes lung adenocarcinoma tumourigenesis and immune evasion.

ABSTRACT:

Rationale

Interleukin-11 (IL-11) has emerged as a significant player in tumourigenesis, with implications across various cancer types. However, its specific role in driving tumour progression in lung adenocarcinoma (LUAD) remains elusive. IL-11's multifaceted impact on both tumour cells and the tumour microenvironment underscores its potential as a therapeutic target in LUAD. This study aims to unravel the involvement of IL-11 in LUAD progression and its influence on the tumour microenvironment.

Methods

Here, we used transcriptomic and digital spatial profiling analyses together with clinic data from two retrospective LUAD patient cohorts. LUAD cell lines genetically engineered to overexpress or to silence IL-11 or its receptor (IL-11RA) were used for in vitro functional ana

SUBMITTER: Cirauqui C 

PROVIDER: S-EPMC12268789 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature