Single-Pulse Response LA-ICP-MS Imaging with Quadrupole Instrumentation: Theoretical Considerations and Practical Assessment.

ABSTRACT: Recent instrumental developments in LA-ICP-MS, such as rapid response cells that significantly reduce the washout and the introduction of high-repetition rate lasers, have greatly impacted the field. To fully take advantage of these developments, improvements on the ICP-MS side were necessary. This was achieved by establishing ICP-TOF-MS instruments enabling simultaneous multielement detection suitable for recording the short transient signals generated by modern rapid response cells. These developments enabled a new operational mode for imaging called the single-pulse response (SPR). Nevertheless, quadrupole-based ICP-MS (ICP-Q-MS) instruments are still the most prevalent instrument type nowadays. Even though it provides many benefits, SPR-based imaging has not yet been applied to ICP-Q-M

SUBMITTER: Willner J 

PROVIDER: S-EPMC12268819 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature