Long-term left ventricular ejection function in fulminant and non-fulminant myocarditis: A multicenter study in China.

ABSTRACT:

Background

There is a gap regarding comparisons of left ventricular ejection fraction (LVEF) changes between fulminant myocarditis (FM) and non-FM (NFM) patients at different follow-up intervals.

Methods

This multicenter retrospective study included 324 patients (163 FM and 161 NFM) with confirmed acute myocarditis through endomyocardial biopsy (EMB) or cardiac magnetic resonance imaging. We used multi-model adjustment approach and a mixed-effects model to comprehensively evaluate changes in LVEF in FM relative to NFM, considering both dichotomous outcome (primary outcome) and repeated measurements outcome (secondary outcome). Sensitivity analysis was conducted for patients aged 15 years and older.

Results

FM patients exhibited a higher risk of the primary outcome (LV

SUBMITTER: Li G 

PROVIDER: S-EPMC12268841 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature