Impact of pre-operative inflammatory markers on overall and disease-free survival of octogenarian patients undergoing video-assisted thoracoscopic lobectomy for early-stage lung cancer: a multicenter study.

ABSTRACT:

Background

The proportion of octogenarian patients who undergo surgery for lung cancer is growing over recent years. Elderly patients are characterized by age-related changes, such as inflammatory modifications of the lower respiratory tract, responsible for structural and functional alterations and tumor progression. Inflammatory markers (IMs) are a well-known prognostic factor in several tumor types, but they have not been analyzed extensively in octogenarian patients submitted to thoracoscopic lobectomy for early-stage lung cancer. The aim of our study is to assess the impact of the pre-operative IMs on the overall survival (OS), disease-free survival (DFS), and post-operative complications of this subset of patients.

Methods

We conducted a retrospective and multi-institu

SUBMITTER: Grossi W 

PROVIDER: S-EPMC12268854 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature