Stereotactic ablative body radiation therapy for treatment of ultra-central lung tumors: a narrative review.

ABSTRACT:

Background and objective

Stereotactic ablative radiotherapy (SABR) has become the standard treatment for medically inoperable peripherally and centrally located stage I non-small cell lung cancer (NSCLC). However, ultra-central (UC) lung tumors pose unique challenges due to their proximity to vital structures, resulting in heightened risks of severe toxic effects. Recent studies have made significant strides in advancing SABR for these challenging cases. This review aims to clarify the definitions of UC lung lesions, examine various SABR dose regimens, assess constraints for critical normal structures, and evaluate outcomes related to local control, overall survival and toxicity profile following SABR for lung lesions.

Methods

We conducted a comprehensive literature search i

SUBMITTER: Sun L 

PROVIDER: S-EPMC12268857 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature