A predictive model based on immune related genes for diffuse large B cell lymphoma (DLBCL).

ABSTRACT:

Background

Anti-tumor immunity is the front line of human response to malignancy, which may shed light on early diagnosis of diffuse large B cell lymphoma (DLBCL). We aim at the introduction of immune-related genes to bring new insight in the establishment of a predictive model to facilitate the diagnosis of DLBCL and guide its therapy.

Methods

First, we identified immune-related genes in DLBCL via GeneCards. With these genes, we conducted least absolute shrinkage and selection operator (LASSO) regression to select the genes with significant contribution to DLBCL and established a validated risk model to generate risk score. Later, a nomogram combining risk score with other common clinical index (age, gender, stage) was established to comprehensively evaluate the survival pr

SUBMITTER: Sun R 

PROVIDER: S-EPMC12268872 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature