Construction of a prognostic model for lung adenocarcinoma based on disulfidptosis-related lncRNAs.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is the most common pathological type of lung cancer, and it has a high incidence and poor prognosis. Disulfidptosis is a novel form of death induced by disulfide stress caused by excessive intracellular cystine accumulation under glucose starvation conditions. This study investigated the significance of disulfidptosis-related long non-coding RNAs (DRlncRNAs) in the risk assessment and prognosis prediction of LUAD.

Methods

RNA sequencing data and clinical information of LUAD patients were obtained from The Cancer Genome Atlas database. Differentially expressed genes associated with disulfidptosis were screened using univariate Cox regression analysis. A prognostic model was constructed using the least absolute shrinkage and selection oper

SUBMITTER: Sun M 

PROVIDER: S-EPMC12268875 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature