Guanine monophosphate synthase-mediated nuclear and mitochondrial communication in the progression of gastric cancer.

ABSTRACT:

Background

Aberrant regulation of guanine monophosphate synthase (GMPS) and serine hydroxymethyltransferase 2 (SHMT2) has been associated with abnormal cell growth, survival, and death in cancer models. This research endeavors to elucidate how the interplay between GMPS and SHMT2 in the nucleus and mitochondria can affect the viability, programmed cell death, and mitochondrial self-degradation of neoplastic cells.

Methods

The study utilized bioinformatics analysis to investigate the interaction mechanism between GMPS and SHMT2. Subsequently, enzyme-linked immunosorbent assay was utilized to assess the levels of GMPS, SHMT2, and TP53 in serum samples obtained from both gastric cancer (GC) patients and control subjects. Furthermore, the study examined the impact of GMPS knocko

SUBMITTER: Guo X 

PROVIDER: S-EPMC12268878 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature