Hepatitis B virus core/capsid protein induces hepatocellular carcinoma progression via long non-coding RNA KCNQ1OT1/miR-335-5p/CDC7 axis.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is the sixth most common malignancy and the fourth leading cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) are dysregulated in various malignancies. However, the mechanisms by which lncRNA influences HCC remain unclear. The aim of this study was to reveal a novel mechanism of lncRNA in HCC progression.

Methods

Differentially expressed (DE) analyses were performed to identify DE lncRNAs, DE microRNAs (miRNAs), and DE messenger RNAs (mRNAs) in HCC and normal tissues from The Cancer Genome Atlas (TCGA) database. The competing endogenous RNA (ceRNA) network of DE genes was constructed using the ENCORI/starBase database. The potential binding sites among the components of the ceRNA regulatory axis were predicted u

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12268880 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature