Silencing PPA1 promotes the survival of non-small cell lung cancer A549 cells under glucose-starved conditions.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) is a malignant tumor with extremely high morbidity and mortality. The large demand for energy during its progression is highly dependent on glucose. The energy metabolism enzyme inorganic pyrophosphatase 1 (PPA1) can mediate the progression of NSCLC through various pathways. Bioinformatics analysis revealed a potential relationship between PPA1 and glycolysis pathway. This study further examined the regulatory effect of silencing PPA1 on the survival of A549 human NSCLC cells under glucose-starved conditions.

Methods

The glycolysis-related gene set was obtained through the gene set enrichment analysis (GSEA) of the Molecular Signatures Database to form a glycolysis gene set, and the potential relationship between PPA1 and glycoly

SUBMITTER: Wang S 

PROVIDER: S-EPMC12268889 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature