Diagnosis and multimodality treatment of primary malignant tracheal tumors.

ABSTRACT: Primary malignant tracheal tumors (PMTTs) are rare, representing less than 0.5% of all cancers. The predominant histological variants are adenoid cystic carcinoma and squamous cell carcinoma. Because of the trachea's functional reserve, symptoms often appear only after significant airway obstruction, delaying diagnosis. Surgical resection with primary reconstruction is the preferred treatment when feasible. Resections longer than 40 mm are associated with higher anastomotic risk, and the decision between complete (R0) or microscopically incomplete (R1) resections must consider patient-specific anatomy and the potential for adjuvant radiotherapy. In selected cases, R1 resection followed by radiation achieves outcomes comparable to R0 resection. Endoscopic interventions can restore airway pa

SUBMITTER: Bibas BJ 

PROVIDER: S-EPMC12268890 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature