Systemic immune response induced by radiofrequency ablation versus microwave ablation at varying powers in murine models of hepatocellular carcinoma.

ABSTRACT:

Background

Thermal ablation for orthotopic tumors can activate the immune system, eliciting tumor-specific immune responses. With the recognition of the immune system's role in cancer outcomes and the demand for effective immunotherapies, there is a clinical need to optimize ablation techniques to enhance anti-tumor immunity. This study evaluates the effects of microwave ablation (MWA) and radiofrequency ablation (RFA) at varying powers and durations on systemic T cell profiles and cytokine levels.

Methods

Subcutaneous murine hepatocellular carcinoma (HCC) models were established. A total of 50 mice were randomly allocated into five groups, with 10 mice in each group: high-power MWA (10 W, 30 s), low-power MWA (5 W, 60 s), high-power RFA (10 W, 30 s), low-power RFA (5 W, 60

SUBMITTER: Qi X 

PROVIDER: S-EPMC12268891 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature