Theaflavin inhibits the malignant phenotype of human anaplastic thyroid cancer 8305C cells by regulating lipid metabolism via PI3K/AKT signaling.

ABSTRACT:

Background

Anaplastic thyroid cancer (ATC) is a rare but extremely aggressive type of thyroid cancer derived from follicular cells of the thyroid gland. Due to the rapid growth of neck masses in ATC patients, which can lead to asphyxia, multimodality therapy, including surgery, chemotherapy, and radiotherapy, is essential in the treatment of ATC. Theaflavin (TF) has anti-cancer effects; however, no study has examined whether TF inhibits the malignant progression of ATC. Therefore, this study was conducted to explore the effects of TF on ATC and to provide a preliminary exploration of its mechanism.

Methods

The effects of TF on the half-maximal inhibitory concentration (IC₅₀) and proliferation of 8305C cells were determined by Cell Counting Kit-8 (CCK-8) assay. The

SUBMITTER: Cai S 

PROVIDER: S-EPMC12268892 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature