Knockdown of MIR205HG prevents cell proliferation, migration and invasion through autophagy and ferroptosis pathways in lung adenocarcinoma.

ABSTRACT:

Background

The MIR205 host gene (MIR205HG) has been reported to play important roles in various cancers. However, its role in the occurrence and development of lung cancer remains to be clarified. This study aimed to analyze the function and molecular mechanisms of MIR205HG in lung adenocarcinoma (LUAD).

Methods

The RNA sequencing (RNA-Seq) dataset was used to examine MIR205HG expression. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to analyze the expression of MIR205HG in LUAD tissues and adjacent tissues. It was also employed to examine the expression of MIR205HG in LUAD cell lines. Water-Soluble Tetrazolium 1 (WST-1), colony formation assay, transwell assay and flow cytometry assay were used to explore the function of MIR205HG in lung ca

SUBMITTER: Huang Z 

PROVIDER: S-EPMC12268893 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature