Proteomics-based prognostic signature in colon adenocarcinoma patients with familial adenomatous polyposis.

ABSTRACT:

Background

Familial adenomatous polyposis (FAP) is regarded as a precancerous stage of colon adenocarcinoma (COAD). COAD concurrent with FAP is quite rare in colorectal cancer screening. In order to create a new COAD prognostic prediction model and to shed light on the landscape of the tumor immune microenvironment in COAD, we examined differentially expressed genes (DEGs) between COAD and FAP in this study.

Methods

DEGs between COAD and FAP were identified using proteomic technology. Expression matrix data for COAD were obtained from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases. Using multivariate and least absolute shrinkage and selection operator (LASSO) regression analyses, a prognostic risk model for COAD concurrent with FAP (COAD-FAP)

SUBMITTER: Li SQ 

PROVIDER: S-EPMC12268895 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature