Multifunctional hydrogel promotes rotator cuff healing through anti-inflammation and vascularization.

ABSTRACT: Rotator cuff tears (RCTs) represent a substantial clinical challenge due to their intricate, multi-stage healing process, which encompasses sequential phases of inflammation, proliferation, tissue reconstruction, and remodeling. Disruption of any phase can adversely affect healing and increase the risk of re-tear. To address this issue, we engineered an injectable LA-CMCS-OHA hydrogel by physically blending lactic acid (LA)-a key signaling molecule-into a composite hydrogel system consisting of carboxymethyl chitosan (CMCS) and oxidized hyaluronic acid (OHA). The hydrogel formation was facilitated by a dynamic Schiff base reaction between CMCS and OHA, imparting superior biocompatibility, injectability, and self-healing properties. The LA-CMCS-OHA hydrogel effectively inhibits nuclear fact

SUBMITTER: Wang B 

PROVIDER: S-EPMC12268896 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature