Decellularized cartilage scaffolds derived from wharton's jelly facilitate cartilage regeneration and inhibit angiogenesis.

ABSTRACT: The avascular nature of articular cartilage severely limits its ability to self-repair after injury, which poses a challenge for clinical treatment, and tissue engineering aims to address this issue with scaffold-based strategies. However, the defining characteristics of an optimal scaffold remain controversial. In this study, we prepared two types of decellularized wharton's jelly (dWJ) scaffolds by trypsin combined with repeated freeze-thawing (TFT) and nuclease combined with repeated freeze-thawing (NFT), respectively. The scaffolds were tested with general characterization, decellularization effect, extracellular matrix (ECM) composition and structure retention, mechanical properties, biocompatibility, in vivo and in vitro chondrogenic effects, and in vitro anti-angiogenic effects. The

SUBMITTER: Gao F 

PROVIDER: S-EPMC12268936 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature