Amino acid intake, plasma metabolites, and incident type 2 diabetes risk: a systematic approach in prospective cohort studies.

ABSTRACT:

Background

Amino acid (AA) intake is thought to be closely related to the etiology of type 2 diabetes (T2D), although few prospective human studies have examined the association. The study prospectively examined inter-relationships among the intake of all 20 AAs, blood metabolome, and T2D incidence.

Methods

Prospective associations between 20 individual AA intake and T2D were examined among 201,113 participants from the Health Professionals Follow-up Study (HPFS), Nurses' Health Study (NHS), and NHSII who did not have T2D, cardiovascular disease, or cancer at baseline. Next, a multi-metabolite signature responsive to AA intake was derived through two sets of 7-day diet record (7DDR) assessments, and subsequently replicated in multiple cohorts. Finally, Cox regression models

SUBMITTER: Wang S 

PROVIDER: S-EPMC12269111 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature