Rod-shaped microglia represent a morphologically distinct subpopulation of disease-associated microglia.

ABSTRACT: Microglia, resident immune cells of the central nervous system, play an essential role in responding to pathological conditions by adopting diverse activation states and morphologies. Recent single-cell RNA sequencing have revealed that microglial subtypes were heterogeneous based on their gene expression profiles. However, the mechanism on how morphological changes in microglia are correlated with their gene expression profiles remains unclear. The current study aimed to identify a distinct population of rod-shaped microglia, characterized by an elongated morphology, in glutamyl cysteine ligase (GCLC)-deficient mice, a model of glutathione deficiency-induced oxidative stress. In the process of brain atrophy accompanied by neuronal cell death, which was observed in GCLC-KO mice, the rod-sh

SUBMITTER: Matsuba Y 

PROVIDER: S-EPMC12269120 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature