Prunus amygdalus var. amara seed extract enhances the antileishmanial activity of miltefosine.

ABSTRACT:

Background

Leishmaniasis, an infectious disease transmitted via sand flies is caused by the protozoan parasite of Leishmania spp. The treatment of this disease is quite challenging due to the high cost, resistance, and toxicity of conventional drugs. Various research studies have demonstrated that plant based drug possess least toxicity, anti-inflammatory and anti-oxidant properties. Here, evaluation of anti-leishmanial activity of methanolic Prunus amygdalus var. amara seed extract was conducted and found that it inhibited L. donovani proliferation and cause apoptosis. Moreover, its combinations with miltefosine enhanced antileishmanial effects. GC-MS analysis confirmed the presence of various phytochemicals in the extract that contributed pharmacological efficacy. These findings

SUBMITTER: Akand SK 

PROVIDER: S-EPMC12269125 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature