Mediating role of systemic inflammation on the association between periodontitis and gestational diabetes mellitus: a cross-sectional study.

ABSTRACT:

Objectives

This study aimed to explore the relationship between periodontitis and gestational diabetes mellitus (GDM) and to ascertain the role of systemic inflammation in mediating this association.

Methods

Data from 5,283 women of reproductive age ranging from 20 to 44 years were retrieved from the National Health and Nutrition Examination Survey (NHANES) III (1988-1994) and NHANES 2009-2014 cycles. The female participants were categorized into three groups: non-diabetes, DM, and GDM. Multivariate logistic and linear regression models were employed to assess the correlations between periodontal variables and diabetes status. Additionally, a mediation analysis was performed to explore the role of systemic inflammatory biomarkers.

Results

Compared to non-periodontitis

SUBMITTER: Cheng J 

PROVIDER: S-EPMC12269137 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature