Risk of Developing Alzheimer Disease in Relation to Common Infections.

ABSTRACT:

Introduction

Many studies demonstrate positive associations between infections and Alzheimer disease (AD), suggesting that brain and/or systemic inflammation may impact AD pathogenesis. However, studies of meningitis and AD risk have been limited to animal models or small human cohorts in the USA. The objective of this study was to examine the relationship between incident AD and three different types of infections (meningitis, pneumonia, and urinary tract infections [UTIs]) using a population-based sample of US Medicare beneficiaries.

Methods

We created a case-control dataset by frequency matching 4:1 (control:case) by age group, sex, and month/year of the date of AD diagnosis or control selection date. We identified 52,628 newly diagnosed AD cases and 210,512 population-ba

SUBMITTER: Camacho-Soto A 

PROVIDER: S-EPMC12269148 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature