The product of waist-to-height ratio and glycated hemoglobin, a novel predictor of diabetes in East Asian populations: insights from two large East Asian cohort studies.

ABSTRACT:

Background

The global incidence of diabetes is increasing annually, with a notable rise in East Asia. This study aimed to develop a novel clinical indicator for predicting the onset of diabetes, based on two longitudinal East Asian cohorts. The clinical utility of the proposed indicator was evaluated by comparing its predictive performance against established metabolic markers.

Methods

A total of 14,468 participants from the NAFLD (Non-Alcoholic Fatty Liver Disease) in the Gifu Area Longitudinal Analysis (NAGALA) cohort and 8,977 from the China Health and Retirement Longitudinal Study (CHARLS) were enrolled for health screenings. The novel Waist-to-Height-Hemoglobin A1c (WHH) indicator was calculated using the formula: waist circumference (cm)/height (cm) × HbA1c × 100. The

SUBMITTER: Wang L 

PROVIDER: S-EPMC12269157 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature