Integrated analysis of blood microbiome and metabolites reveals key biomarkers and functional pathways in myocardial infarction.

ABSTRACT:

Background

Myocardial infarction (MI) has been linked to changes in the blood microbiome, yet the interplay between microbiome and metabolome remains poorly understood. This study integrates blood microbiome profiling and metabolomic analysis to uncover biomarkers and pathways associated with MI.

Methods

Using 16 S rRNA sequencing and LC-MS metabolomics, blood samples from 24 MI patients and 24 healthy controls were analyzed. Microbial diversity, key taxa, metabolites, and their functional implications were evaluated.

Results

While alpha and beta diversity of the microbiome showed no significant differences, three bacterial taxa (Proteobacteria, Gammaproteobacteria, and Bacilli) and twenty metabolites (e.g., UPD-L-Ara4O, Urotensin-related peptide, and 9-hydroxy octade

SUBMITTER: Khan I 

PROVIDER: S-EPMC12269162 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature