Evaluating pentraxin 3 as a diagnostic biomarker for diabetic retinopathy: a systematic review and meta-analysis.

ABSTRACT:

Background

Pentraxin 3 (PTX3), a novel biomarker of vascular inflammation and endothelial dysfunction, has been identified as a potential predictor of diabetic retinopathy (DR). This meta-analysis aimed to assess the association between circulating PTX3 levels and both the presence and severity of DR in patients with diabetes.

Methods

A systematic literature search was conducted across PubMed, Web of Science, Embase, Scopus, and Google Scholar up to January 2025. Observational studies comparing PTX3 levels between patients with and without DR, as well as proliferative (PDR) and non-proliferative (NPDR) stages, were considered. Standardized mean differences (SMD) with 95% confidence intervals (CI) were calculated using random effects models.

Results

A total of 15 studi

SUBMITTER: Mohammadpour Fard R 

PROVIDER: S-EPMC12269163 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature