Integrative evidence linking excessive daytime sleepiness, narcolepsy, and hypertension: insights from NHANES, Mendelian randomization, and proteomics.

ABSTRACT:

Background

This study aimed to explore associations and causality between excessive daytime sleepiness (EDS), narcolepsy, and hypertension.

Methods

Publicly available data from the National Health and Nutrition Examination Survey (NHANES), genome-wide association studies (GWAS), and protein quantitative trait locus (pQTL) data sets were used for analysis. Logistic regression models assessed the association between different frequencies of EDS and hypertension, and sex-stratified subgroup analyses were also performed. Bi-directional Mendelian randomization (MR) evaluated the causal effect of narcolepsy on hypertension. Proteome-wide MR and colocalization analyses were conducted to identify potential protein biomarkers and shared genetic variants.

Results

EDS with diffe

SUBMITTER: Feng S 

PROVIDER: S-EPMC12269179 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature