The narrow window of protection: protective efficacy of maternally derived antibodies against virulent classical swine fever virus in Japan.

ABSTRACT: This study investigated the protective efficacy of maternally derived antibodies (MDAs) against the currently circulating virulent classical swine fever virus (CSFV) strain in Japan (JPN/1/2018). Thirty-eight piglets from guinea-pig exaltation of Newcastle disease virus-negative phenomenon (GPE^-)-vaccinated (Groups 1-2) or unvaccinated sows (Group 3) were divided into three groups: Group 1 (n = 16, MDA titres < 2 to 5.6 against JPN/1/2018), Group 2 (n = 16, MDA titres 45-362), and Group 3 (n = 6, no MDAs). All piglets were orally challenged with the JPN/1/2018 strain and monitored for clinical signs, viremia, viral shedding, and viral tissue distribution. Groups 1 and 3 showed similar clinical manifestations, viremia, viral shedding and viral distribution patterns, whereas Group

SUBMITTER: Fukai K 

PROVIDER: S-EPMC12269211 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature