Identification and evaluation of metabolic mRNAs and key miRNAs in colorectal cancer liver metastasis.

ABSTRACT:

Background

Colorectal cancer (CRC) represents a major global health challenge due to its high lethality, largely attributable to liver metastasis. Despite the established correlation between metabolic reprogramming of cancer cells and their proliferation, invasion, and metastasis, the specific role of metabolism-associated mRNAs in the liver metastasis of CRC remains unelucidated.

Methods

In our research, we procured and analyzed CRC liver metastasis-associated datasets from the GEO database. Subsequently, we employed Weighted Gene Co-expression Network Analysis (WGCNA) to construct an integrated co-expression network of mRNAs and miRNAs, facilitating the identification of pivotal mRNAs and miRNAs. We screened the featured genes using a machine-learning technique, followed b

SUBMITTER: Chen G 

PROVIDER: S-EPMC12269269 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature