Liver injury in post-acute COVID-19 syndrome: A systematic review and meta-analysis of early observational studies.

ABSTRACT:

Background

Post-acute COVID-19 syndrome (PACS; long COVID) is characterized by persistent or delayed symptoms at least 4 weeks from acute COVID-19 infection. Given the well-documented incidence of liver injury in acute COVID-19, this systematic review aims to assess the odds of liver injury in earlier experiencers of PACS.

Methods

Observational studies published prior to March 2022 were screened for data describing liver injury (defined per primary study) in patients with PACS.

Results

A total of 2,117 abstracts and 35 full texts were screened, of which 26 met the inclusion criteria. The mean time since acute COVID infection across all studies was 195.5 days. Seven studies included COVID-negative control groups. Twenty-three studies measured lab findings, and nine stu

SUBMITTER: Mundra P 

PROVIDER: S-EPMC12269275 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature