Comparative Transcriptomes of Canine and Human Prostate Cancers Identify Mediators of Castration Resistance.

ABSTRACT: Prostate cancer continues to be one of the most lethal cancers in men. While androgen deprivation therapy is initially effective in treating prostate cancer, most cases of advanced prostate cancer eventually progress to castration-resistant prostate cancer (CRPC), which is incurable. Similarly, the most aggressive form of prostatic carcinoma occurs in dogs that have been castrated. To identify molecular similarities between canine prostate cancer and human CRPC, we performed a comparative analysis of gene expression profiles. Through this transcriptomic analysis, we found that prostatic carcinoma in castrated dogs demonstrates an androgen-indifferent phenotype, characterised by low-androgen receptor and neuroendocrine-associated genes. Notably, we identified two genes, ISG15 and AZGP1, tha

SUBMITTER: Angel MR 

PROVIDER: S-EPMC12269310 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature